Hydrocortisone

Hydrocortisone (Cortisol) is a steroid hormone or glucocorticoid secreted by the adrenal cortex[1].

Product Specifications

CAS Number

[50-23-7]

Product Name Alternative

Cortisol

UNSPSC

12352211

Hazard Statement

H360, H373

Target

Endogenous Metabolite; Glucocorticoid Receptor

Type

Natural Products

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Endocrinology; Cancer; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/Hydrocortisone.html

Purity

99.94

Solubility

DMSO : 200 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

C[C@@]1([C@@]2(O)C(CO)=O)[C@](CC2)([H])[C@@](CCC3=CC4=O)([H])[C@]([C@]3(CC4)C)([H])[C@@H](O)C1

Molecular Formula

C21H30O5

Molecular Weight

362.46

Precautions

H360, H373

References & Citations

[1]Förster C, et al. Differential effects of hydrocortisone and TNFalpha on tight junction proteins in an in vitro model of the human blood-brain barrier. J Physiol. 2008 Apr 1;586 (7) :1937-49.|[2]Bellinghausen I, et al. Inhibition of human allergic T-cell responses by IL-10-treated dendritic cells: differences from hydrocortisone-treated dendritic cells. J Allergy Clin Immunol. 2001 Aug;108 (2) :242-9.|[3]Chappell D, et al. Hydrocortisone preserves the vascular barrier by protecting the endothelial glycocalyx. Anesthesiology. 2007 Nov;107 (5) :776-84.