(E) -4-Hydroxycrotonic acid

(E) -4-Hydroxycrotonic acid (T-HCA) is a high-affinity ligand for GHB binding sites, with a ki value of 1.1 μM. The introduction of diaryl substituents into (E) -4-Hydroxycrotonic acid significantly enhances its affinity for GHB binding sites, with ki values ranging from 0.023 to 0.075 μM. (E) -4-Hydroxycrotonic acid holds promise for optimizing GHB ligand structures and assisting in the development of effective three-dimensional pharmacophore models[1].

Product Specifications

CAS Number

[24587-49-3]

Product Name Alternative

Trans-4-Hydroxycrotonic acid; trans-γ-Hydroxycrotonic acid; T‐HCA

UNSPSC

12352211

Hazard Statement

H315, H319, H335

Target

GABA Receptor

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/e-4-hydroxycrotonic-acid.html

Purity

99.83

Solubility

DMSO : 175 mg/mL (ultrasonic)

Smiles

O=C(O)/C=C/CO

Molecular Formula

C4H6O3

Molecular Weight

102.09

Precautions

H315, H319, H335

References & Citations

[1]Krall J, et al. Molecular Hybridization of Potent and Selective γ-Hydroxybutyric Acid (GHB) Ligands: Design, Synthesis, Binding Studies, and Molecular Modeling of Novel 3-Hydroxycyclopent-1-enecarboxylic Acid (HOCPCA) and trans-γ-Hydroxycrotonic Acid (T-HCA) Analogs. J Med Chem. 2017 Nov 9;60 (21) :9022-9039.