(E) -4-Hydroxycrotonic acid
(E) -4-Hydroxycrotonic acid (T-HCA) is a high-affinity ligand for GHB binding sites, with a ki value of 1.1 μM. The introduction of diaryl substituents into (E) -4-Hydroxycrotonic acid significantly enhances its affinity for GHB binding sites, with ki values ranging from 0.023 to 0.075 μM. (E) -4-Hydroxycrotonic acid holds promise for optimizing GHB ligand structures and assisting in the development of effective three-dimensional pharmacophore models[1].
Product Specifications
CAS Number
[24587-49-3]
Product Name Alternative
Trans-4-Hydroxycrotonic acid; trans-γ-Hydroxycrotonic acid; T‐HCA
UNSPSC
12352211
Hazard Statement
H315, H319, H335
Target
GABA Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/e-4-hydroxycrotonic-acid.html
Purity
99.83
Solubility
DMSO : 175 mg/mL (ultrasonic)
Smiles
O=C(O)/C=C/CO
Molecular Formula
C4H6O3
Molecular Weight
102.09
Precautions
H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-100982/E-4-Hydroxycrotonic-acid-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-100982/E-4-Hydroxycrotonic-acid-SDS-MedChemExpress.pdf
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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