Rabbit anti Human Lass1 (Crossreacts with GDF1)

LAG1 is a longevity gene, the first such gene to be identified. Originally cloned from the yeast Saccharomyces cerevisiae. A close homolog of this gene, LAC1, has been found in the yeast genome. The Human homolog of LAG1 has functions in Human aging. LAG1 may be involved in neurodegenerative diseases and Human aging. Lass1 may be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing mainly one fatty acid donor (N-linked stearoyl- (C18) ceramide) in a fumonisin B1-independent manner. Located in the endoplasmic reticulum membrane; LAss1 is a multi-pass membrane protein.

Antibody can be used for Western blotting (1:400 starting dilution). Other uses not yet tested. Only reacts with Human Lass1 protein. Also cross reacts with Human GDF1. Optimal concentration should be evaluated by serial dilutions.

This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving Humans or animals.

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