Ceranib1
Ceranib1 is a ceramidase inhibitor. Ceranib1 inhibits ceramidase activity toward an exogenous ceramide analog, induces the accumulation of multiple ceramide species, decreases levels of sphingosine and S1P. Ceranib1 inhibits the proliferation of ovarian cancer cells[1].
Product Specifications
CAS Number
328076-61-5
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
Ceramidase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ceranib1.html
Purity
99.38
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1NC2=C(C=C(C)C=C2)C(C3=CC=CC=C3)=C1C(/C=C/C4=CC=C(OC)C=C4)=O
Molecular Formula
C26H21NO3
Molecular Weight
395.45
Precautions
H315, H319, H320
References & Citations
[1]Draper JM, et al. Discovery and evaluation of inhibitors of human ceramidase. Mol Cancer Ther. 2011 Nov;10 (11) :2052-61.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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