Ac-Exatecan

Ac-Exatecan is acetylation-modified Exatecan (HY-13631) . Exatecan is a common toxin component in ADC preparation (ADC cytotoxin) and an inhibitor of DNA topoisomerase I (IC50 = 2.2 μM) . Exatecan has antitumor activity. Exatecan can be used as a payload for ADC. Exatecan is effective against P-glycoprotein mediated multi-drug resistant cells[1][2].

Product Specifications

CAS Number

[2922852-48-8]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

ADC Payload; Topoisomerase

Type

Reference compound

Related Pathways

Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ac-exatecan.html

Concentration

10mM

Purity

99.02

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(OC1)[C@@](CC)(O)C2=C1C(N3C(C4=NC5=CC(F)=C(C)C6=C5C([C@@H](NC(C)=O)CC6)=C4C3)=C2)=O

Molecular Formula

C26H24FN3O5

Molecular Weight

477.48

Precautions

H302, H315, H319, H335

References & Citations

[1]Mitsui I, et al. A new water-soluble camptothecin derivative, DX-8951f, exhibits potent antitumor activity against human tumors in vitro and in vivo. Jpn J Cancer Res. 1995 Aug;86 (8) :776-82.|[2]Nakada, T., et al., (2016) . Novel antibody drug conjugates containing exatecan derivative-based cytotoxic payloads. Bioorganic & medicinal chemistry letters, 26 (6), 1542–1545.