Ac-Exatecan
Ac-Exatecan is acetylation-modified Exatecan (HY-13631) . Exatecan is a common toxin component in ADC preparation (ADC cytotoxin) and an inhibitor of DNA topoisomerase I (IC50 = 2.2 μM) . Exatecan has antitumor activity. Exatecan can be used as a payload for ADC. Exatecan is effective against P-glycoprotein mediated multi-drug resistant cells[1][2].
Product Specifications
CAS Number
[2922852-48-8]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
ADC Payload; Topoisomerase
Type
Reference compound
Related Pathways
Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ac-exatecan.html
Concentration
10mM
Purity
99.02
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(OC1)[C@@](CC)(O)C2=C1C(N3C(C4=NC5=CC(F)=C(C)C6=C5C([C@@H](NC(C)=O)CC6)=C4C3)=C2)=O
Molecular Formula
C26H24FN3O5
Molecular Weight
477.48
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-79490/Ac-Exatecan-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-79490/Ac-Exatecan-SDS-MedChemExpress.pdf
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Camptothecins
Available Sizes
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