Sigma-1 receptor antagonist 3

Sigma-1 receptor antagonist 3 (compound135) is a potent and selective Sigma-1 (σ1) receptor antagonist with a Ki of 1.14 nM. Sigma-1 receptor antagonist 3 inhibits Human Ether-a-go-go-Related Gene (hERG) with an IC50 of 1.54 μM. Sigma-1 receptor antagonist 3 has the potential for the neuropathic pain[1].

Product Specifications

CAS Number

[1639220-17-9]

UNSPSC

12352005

Hazard Statement

H302-H315-H319

Target

Potassium Channel; Sigma Receptor

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/sigma-1-receptor-antagonist-3.html

Purity

99.47

Solubility

DMSO : 12.5 mg/mL (ultrasonic)

Smiles

CC1=NC(C2=CC=C(F)C=C2)=NC(OCCCN3CCCCC3)=C1Cl

Molecular Formula

C19H23ClFN3O

Molecular Weight

363.86

Precautions

P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501

References & Citations

[1]Lan Y, et al. Synthesis and biological evaluation of novel sigma-1 receptor antagonists based on pyrimidine scaffold as agents for treating neuropathic pain. J Med Chem. 2014 Dec 26;57 (24) :10404-23.