CK1-IN-1
CK1-IN-1 (Compound 1c) is a casein kinase 1 (CK1) inhibitor with IC50 values of 15 nM and 16 nM for CK1δ and CK1ε, respectively. CK1-IN-1 inhibits p38α MAPK with an IC50 of 73 nM. CK1-IN-1 can be used to study cardiomyogenesis[1].
Product Specifications
CAS Number
[1784751-20-7]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Casein Kinase; p38 MAPK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; MAPK/ERK Pathway; Stem Cell/Wnt
Applications
COVID-19-anti-virus
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/ck1-in-1.html
Concentration
10mM
Purity
99.19
Solubility
DMSO : 62.5 mg/mL (ultrasonic)
Smiles
FC1=CC=C(C2=C(C3=CC=NC=C3)NC(C4=CC=C5C=CC=CC5=C4F)=N2)C=C1
Molecular Formula
C24H15F2N3
Molecular Weight
383.39
Precautions
H302, H315, H319, H335
References & Citations
[1]Filip LACO, et al. 2,4,5-tri-substituted azole-based casein kinase 1 inhibitors as inducers for cardiomyogenesis. WO2015119579A1.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CK1; p38α
Available Sizes
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