Lecozotan (hydrochloride)
Lecozotan (SRA-333) hydrochloride is an orally active and selective antagonist of 5-HT1A with a Ki of 4.5 nM for cloned human 5-HT1A receptor. Lecozotan hydrochloride enhances the stimulated release of glutamate and acetylcholine in the hippocampus and possesses cognitive-enhancing properties. Lecozotan hydrochloride has the potential for mild-to-moderate Alzheimer's disease (AD) research[1][2].
Product Specifications
CAS Number
433282-68-9
Product Name Alternative
SRA-333 (hydrochloride)
UNSPSC
12352005
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/lecozotan-hydrochloride.html
Purity
98.71
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(C1=CC=C(C=C1)C#N)N(C2=CC=CC=N2)C[C@H](N3CCN(CC3)C4=C5C(OCCO5)=CC=C4)C.Cl
Molecular Formula
C28H30ClN5O3
Molecular Weight
520.02
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
5-HT1 Receptor; mLAG-3
Available Sizes
Frequently Asked Questions
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