Lecozotan (hydrochloride)

Lecozotan (SRA-333) hydrochloride is an orally active and selective antagonist of 5-HT1A with a Ki of 4.5 nM for cloned human 5-HT1A receptor. Lecozotan hydrochloride enhances the stimulated release of glutamate and acetylcholine in the hippocampus and possesses cognitive-enhancing properties. Lecozotan hydrochloride has the potential for mild-to-moderate Alzheimer's disease (AD) research[1][2].

Product Specifications

CAS Number

[433282-68-9]

Product Name Alternative

SRA-333 (hydrochloride)

UNSPSC

12352005

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/lecozotan-hydrochloride.html

Purity

98.71

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C(C1=CC=C(C=C1)C#N)N(C2=CC=CC=N2)C[C@H](N3CCN(CC3)C4=C5C(OCCO5)=CC=C4)C.Cl

Molecular Formula

C28H30ClN5O3

Molecular Weight

520.02

References & Citations

[1]L E Schechter, et al. Lecozotan (SRA-333) : a selective serotonin 1A receptor antagonist that enhances the stimulated release of glutamate and acetylcholine in the hippocampus and possesses cognitive-enhancing properties. J Pharmacol Exp Ther. 2005 Sep;314 (3) :1274-89. |[2]Alain Patat, et al. Safety, tolerability, pharmacokinetics and pharmacodynamics of ascending single and multiple doses of lecozotan in healthy young and elderly subjects. Br J Clin Pharmacol. 2009 Mar;67 (3) :299-308.