P-SCN-Bn-DOTA
P-SCN-Bn-DOTA is a bifunctional chelating agent. p-SCN-Bn-DOTA can simultaneously chelate radionuclides and link monoclonal antibody for radioimmunoresearch of tumor[1][2].
Product Specifications
CAS Number
127985-74-4
Product Name Alternative
RP 29761,OPC-14857; DM-14857
UNSPSC
12352005
Hazard Statement
H301, H315, H319, H334, H335
Target
Others
Type
Reference compound
Related Pathways
Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/p-scn-bn-dota.html
Purity
99.78
Solubility
DMSO : 20.83 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(O)CN1C(CC2=CC=C(N=C=S)C=C2)CN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CC1
Molecular Formula
C24H33N5O8S
Molecular Weight
551.61
Precautions
H301, H315, H319, H334, H335
References & Citations
[1]Vera DRB, et, al. Preclinical evaluation of (177) lu-nimotuzumab: a potential tool for radioimmunotherapy of epidermal growth factor receptor-overexpressing tumors. Cancer Biother Radiopharm. 2011 Jun;26 (3) :287-97.|[2]Giannini G, et, al. Synthesis and preliminary in vitro evaluation of DOTA-Tenatumomab conjugates for theranostic applications in tenascin expressing tumors. Bioorg Med Chem. 2019 Aug 1;27 (15) :3248-3253.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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