WZ-2-033
WZ-2-033 is a potent STAT3 inhibitor. WZ-2-033 inhibits MDA-MB-231, HCC70, and MDA-MB231-4175 cells proliferation, colony survival, migration, and invasion with IC50s of 0.7, 1.3, and 1.3 μM, respectively[1].
Product Specifications
CAS Number
2416196-47-7
UNSPSC
12352005
Target
STAT
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/wz-2-033.html
Smiles
O=C(CC1=C(C2=CC=C(C(F)(F)F)C=C2)N=C3C=C(C=CN31)OC)NC4=CC5=C(C=CS(=O)5=O)C=C4
Molecular Formula
C25H18F3N3O4S
Molecular Weight
513.49
References & Citations
[1]Zhong Y, et al. The novel STAT3 inhibitor WZ-2-033 causes regression of human triple-negative breast cancer and gastric cancer xenografts. Acta Pharmacol Sin. 2022 Apr;43 (4) :1013-1023.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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