LTURM34

LTURM34 is a specific DNA-PK inhibitor (IC50=34 nM) . LTURM34 exhibits 170-fold selectivity for DNA-PK over PI3K. LTURM34 shows potent antiproliferative activity in a wide range of tumor cell lines[1].

Product Specifications

CAS Number

[1879887-96-3]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

DNA-PK

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/LTURM34.html

Purity

99.35

Solubility

DMSO : 65 mg/mL (ultrasonic)

Smiles

O=C1C2=CC=CC(C3=CC=CC4=C3SC5=C4C=CC=C5)=C2OC(N6CCOCC6)=N1

Molecular Formula

C24H18N2O3S

Molecular Weight

414.48

Precautions

H302, H315, H319, H335

References & Citations

[1]Morrison R, et al. Synthesis, structure elucidation, DNA-PK and PI3K and anti-cancer activity of 8- and 6-aryl-substituted-1-3-benzoxazines. Eur J Med Chem. 2016 Mar 3;110:326-39.