(4R,5S) -Nutlin carboxylic acid

(4R,5S) -Nutlin carboxylic acid is the Nutlin 3-based MDM2 ligand. (4R,5S) -Nutlin carboxylic acid can be connected to the ligand for protein by a linker to form PROTACs[1].

Product Specifications

CAS Number

[2306390-08-7]

Product Name Alternative

MDM2 ligand 2; E3 ligase Ligand 15

UNSPSC

12352005

Hazard Statement

H315-H319-H335

Target

Ligands for E3 Ligase

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/e3-ligase-ligand-15.html

Solubility

10 mM in DMSO

Smiles

O=C1N(CC(O)=O)CCN(C(N2[C@@H](C3=CC=C(Cl)C=C3)[C@@H](C4=CC=C(Cl)C=C4)N=C2C5=CC=C(OC)C=C5OC(C)C)=O)C1

Molecular Formula

C32H32Cl2N4O6

Molecular Weight

639.53

Precautions

P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

References & Citations

[1]Shibata N, et al. Development of Protein Degradation Inducers of Androgen Receptor by Conjugation of Androgen Receptor Ligands and Inhibitor of Apoptosis Protein Ligands. J Med Chem. 2018 Jan 25;61 (2) :543-575.