Canrenone-d4

Canrenone-d4 is deuterium labeled Canrenone. Canrenone (Aldadiene) is an aldosterone antagonist extensively used as a diuretic agent.

Product Specifications

Product Name Alternative

Aldadiene-d4; SC9376-d4

UNSPSC

12352005

Target

Endogenous Metabolite; Isotope-Labeled Compounds; Mineralocorticoid Receptor

Type

Isotope-Labeled Compounds

Related Pathways

Metabolic Enzyme/Protease; Others; Vitamin D Related/Nuclear Receptor

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Solubility

10 mM in DMSO

Smiles

C[C@@]12[C@]3(CC([2H])([2H])C(O3)=O)CC[C@@]1([H])[C@]4([H])C=CC5=CC(C([2H])([2H])C[C@]5(C)[C@@]4([H])CC2)=O

Molecular Formula

C22H24D4O3

Molecular Weight

344.48

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Caligiuri A, et al. Antifibrogenic effects of canrenone, an antialdosteronic drug, on human hepatic stellate cells. Gastroenterology. 2003 Feb;124 (2) :504-20.|[3]Erbler HC, et al. Effect of spironolactone and its main metabolite canrenone on the renin-angiotensin-aldosterone-system during long-term treatment in rats. Acta Endocrinol (Copenh) . 1979 Jan;90 (1) :147-56.|[4]Erbler HC, et al. On the mechanism of the inhibitory action of the spirolactone SC 9376 (aldadiene) on the production of corticosteroids in rat adrenals in vitro. Naunyn Schmiedebergs Arch Pharmacol. 1973;277 (2) :139-49.