Riociguat (Standard)

Riociguat (Standard) is the analytical standard of Riociguat. This product is intended for research and analytical applications. Riociguat is an oral stimulator of soluble guanylate cyclase (sGC) used in the treatment of pulmonary hypertension.

Product Specifications

CAS Number

[625115-55-1]

Product Name Alternative

BAY 632521 (Standard)

UNSPSC

12352005

Hazard Statement

H301-H361-H410

Target

Guanylate Cyclase; Reference Standards

Type

Reference Standards

Related Pathways

GPCR/G Protein; Others

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/riociguat-standard.html

Smiles

FC1=CC=CC=C1CN2C3=NC=CC=C3C(C4=NC(N)=C(C(N)=N4)N(C)C(OC)=O)=N2

Molecular Formula

C20H19FN8O2

Molecular Weight

422.42

Precautions

P264-P270-P273-P280-P391-P405-P501

References & Citations

[1]Schermuly RT, et al. Expression and function of soluble guanylate cyclase in pulmonary arterial hypertension. Eur Respir J. 2008 Oct;32 (4) :881-91.|[2]Schermuly RT, et al. Riociguat for the treatment of pulmonary hypertension. Expert Opin Investig Drugs. 2011 Apr;20 (4) :567-76.|[3]Donda K, et al. Riociguat prevents hyperoxia-induced lung injury and pulmonary hypertension in neonatal rats without effects on long bone growth. PLoS One. 2018 Jul 10;13 (7) :e0199927.