NE 10790
NE 10790, a poor farnesyl pyrophosphate synthase inhibitor, is a phosphonocarboxylate analogue of the potent bisphosphonate risedronate and is a weak antiresorptive agent.
Product Specifications
CAS Number
152831-36-2
Product Name Alternative
3-PEHPC
UNSPSC
12352005
Hazard Statement
H302, H312, H332
Target
Farnesyl Transferase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/NE_10790.html
Purity
99.50
Solubility
0.1 M NaOH : 10 mg/mL (ultrasonic) |1 M NaOH : ≥ 100 mg/mL|H2O : 1.67 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
OC(C(O)=O)(P(O)(O)=O)CC1=CC=CN=C1
Molecular Formula
C8H10NO6P
Molecular Weight
247.14
Precautions
H302, H312, H332
References & Citations
[1]Coxon FP, et al. Identification of a novel phosphonocarboxylate inhibitor of Rab geranylgeranyl transferase that specifically prevents Rab prenylation in osteoclasts and macrophages. J Biol Chem. 2001 Dec 21;276 (51) :48213-22.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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