NE 10790

NE 10790, a poor farnesyl pyrophosphate synthase inhibitor, is a phosphonocarboxylate analogue of the potent bisphosphonate risedronate and is a weak antiresorptive agent.

Product Specifications

CAS Number

[152831-36-2]

Product Name Alternative

3-PEHPC

UNSPSC

12352005

Hazard Statement

H302, H312, H332

Target

Farnesyl Transferase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/NE_10790.html

Purity

99.50

Solubility

0.1 M NaOH : 10 mg/mL (ultrasonic) |1 M NaOH : ≥ 100 mg/mL|H2O : 1.67 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

OC(C(O)=O)(P(O)(O)=O)CC1=CC=CN=C1

Molecular Formula

C8H10NO6P

Molecular Weight

247.14

Precautions

H302, H312, H332

References & Citations

[1]Coxon FP, et al. Identification of a novel phosphonocarboxylate inhibitor of Rab geranylgeranyl transferase that specifically prevents Rab prenylation in osteoclasts and macrophages. J Biol Chem. 2001 Dec 21;276 (51) :48213-22.