SQLE-IN-1
SQLE-IN-1 (compound 19) is a squalene epoxidase (SQLE) inhibitor. SQLE-IN-1 inhibits the proliferation and migration of Huh7 cells. SQLE-IN-1 inhibits the cell cholesterol generation. SQLE-IN-1 increases the expression of PTEN and inhibits PI3K and AKT[1].
Product Specifications
CAS Number
1019169-83-5
UNSPSC
12352005
Target
Akt; PI3K; PTEN
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/sqle-in-1.html
Purity
98.15
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=S(C1=CC=C(F)C=C1F)(NC2=CC=C(NC3=NC(C)=NC(NC4=CC=C(C)C=C4)=C3)C=C2)=O
Molecular Formula
C24H21F2N5O2S
Molecular Weight
481.52
References & Citations
[1]Liu, Yayun, et al. Novel squalene epoxidase inhibitor and application thereof in preparation of anti-liver cancer drugs. China, CN116987037. 2023-11-03.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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