Anti-Hu CD62E Purified
CD62E (E-selectin) is a type I transmembrane glycoprotein of 97 - 115 kDa. It recognizes carbohydrate ligands on various molecules, and promotes leukocyte extravasation by mediating leukocyte rolling on activated endothelia during inflammation. CD62E is expressed above all in inflammated endothelium, but it can also be found on resting endothelium in certain organs, such as skin, or placenta.
Product Specifications
Certification
RUO
Reactivity
Human
Immunogen
TNF-activated HUVEC and human CD40 cDNA-transfected cells
Target Antigen
CD62E
Clone
HAE-1f
Applications
FC (QC tested), ICC
Concentration
1 mg/mL
Format
Purified
Buffer
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
References & Citations
*Tu L, Chen A, Delahunty MD, Moore KL, Watson SR, McEver RP, Tedder TF: L-selectin binds to P-selectin glycoprotein ligand-1 on leukocytes: interactions between the lectin, epidermal growth factor, and consensus repeat domains of the selectins determine ligand binding specificity. J Immunol. 1996 Nov 1;157 (9) :3995-4004., URL: https://pubmed.ncbi.nlm.nih.gov/8892633/, *Trappenburg MC, van Schilfgaarde M, Marchetti M, Spronk HM, ten Cate H, Leyte A, Terpstra WE, Falanga A: Elevated procoagulant microparticles expressing endothelial and platelet markers in essential thrombocythemia. Haematologica. 2009 Jul;94 (7) :911-8. , URL: https://www.ncbi.nlm.nih.gov/pubmed/19508974
Storage Conditions
Store at 2-8°C. Do not freeze.
Specificity
The mouse monoclonal HAE-1f recognizes an extracellular epitope of CD62E, a transmembrane glycoprotein expressed on activated endothelial cells, as well as in skin, placenta, and bone marrow endothelium.
Applications Notes
Flow cytometry: Recommended dilution: 1-4 μg/ml.
Isotype
Mouse IgG1 kappa
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