T-518
Product Specifications
UNSPSC Description
T-518 is an orally active, selective, and blood-brain barrier permeable HDAC6 inhibitor with an IC50 value of 36 nM for human HDAC6. T-581 can be used in research on tauopathy[1].
Target Antigen
HDAC
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage;Epigenetics
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/t-518.html
Solubility
10 mM in DMSO
Smiles
O=C(C(F)(F)C(F)(F)F)N[C@H]1[C@H](N2CC3=NC=C(C4=NN=C(C(F)F)O4)C=C3C2=O)CCCC1
Molecular Weight
495.35
References & Citations
[1]Onishi T, et al. A novel orally active HDAC6 inhibitor T-518 shows a therapeutic potential for Alzheimer's disease and tauopathy in mice. Sci Rep. 2021 Jul 29;11(1):15423. |[2]König B, et al. 2-(Difluoromethyl)-1, 3, 4-oxadiazoles: The Future of Selective Histone Deacetylase 6 Modulation?[J]. ACS Pharmacology & Translational Science, 2024.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-161307/T-518-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-161307/T-518-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2276680-91-0
Available Sizes
Curated Selection
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