MT-4

MT-4 is a derivative of a tissue transglutaminase (TG2) inhibitor. MT-4 targets the complex of TG2 and fibronectin (FN) (TG2/FN) and inhibits the adhesion of tumor cells to the matrix. MT-4 inhibits the adhesion of ovarian cancer (OC) cells to the peritoneum and increases the sensitivity of OC cells to paclitaxel.

Product Specifications

CAS Number

[2327925-35-7]

UNSPSC

12352005

Target

Transglutaminase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/mt-4.html

Concentration

10mM

Purity

99.84

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CN(C)C1=NC(NC2=CC=C(NC(CC3=CC=CC=C3)=O)C=C2)=NC(C)=C1

Molecular Formula

C21H23N5O

Molecular Weight

361.44

References & Citations

[1]Sima LE, et al. Small Molecules Target the Interaction between Tissue Transglutaminase and Fibronectin. Mol Cancer Ther. 2019 Jun;18 (6) :1057-1068.