Micafungin (sodium)

Micafungin sodium (FK 463 sodium) is an antifungal agent which inhibits 1, 3-beta-D-glucan synthesis.

Product Specifications

CAS Number

[208538-73-2]

Product Name Alternative

FK 463 (sodium)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Antibiotic; Fungal

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection; Cancer

Assay Protocol

https://www.medchemexpress.com/Micafungin-sodium.html

Purity

99.26

Solubility

DMSO : 116.67 mg/mL (ultrasonic)

Smiles

O=S(OC1=CC([C@H](O)[C@@H](O)C(NC(C2N(C(C(NC([C@]([H])(C[C@@H](O)[C@@H](O)NC(C3N(C(C([C@H](O)CC(N)=O)N4)=O)C[C@H](C)[C@@H]3O)=O)NC(C5=CC=C(C6=NOC(C7=CC=C(OCCCCC)C=C7)=C6)C=C5)=O)=O)[C@H](O)C)=O)C[C@H](O)C2)=O)C4=O)=CC=C1O)(O[Na])=O

Molecular Formula

C56H70N9NaO23S

Molecular Weight

1292.26

Precautions

H302, H315, H319, H335

References & Citations

[1]Bazzi W, et al. The inhibitory effect of micafungin on biofilm formation by Pseudomonas aeruginosa. Biofouling. 2013 Jul 23.|[2]Kai H, et al. Synergistic antifungal activity of KB425796-C in combination with micafungin against Aspergillus fumigat us and its efficacy in murine infection models. J Antibiot (Tokyo) . 2013 Jun 12.|[3]Tawara S, Ikeda F, Maki K, et al. In vitro activities of a new lipopeptide antifungal agent, FK463, against a variety of clinically important fungi. Antimicrob Agents Chemother. 2000;44 (1) :57-62. |[4]Ikeda F, Wakai Y, Matsumoto S, et al. Efficacy of FK463, a new lipopeptide antifungal agent, in mouse models of disseminated candidiasis and aspergillosis. Antimicrob Agents Chemother. 2000;44 (3) :614-618. |[5]Mikamo H, Sato Y, Tamaya T. In vitro antifungal activity of FK463, a new water-soluble echinocandin-like lipopeptide. J Antimicrob Chemother. 2000;46 (3) :485-487.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture and light)

Scientific Category

Reference compound1

Clinical Information

Launched

Citation 01

Antimicrob Agents Chemother. 2023 Aug 17;67 (8) :e0054323.|Appl Microbiol Biotechnol. 2025 Jan 24;109 (1) :21.|bioRxiv. 2024 May 14.|Chem Biol Interact. 2024 Jul 31:400:111179.|J Clin Microbiol. 2017 Jun;55 (6) :1883-1893.|NPJ Antimicrob Resist. 2025 Apr 17;3 (1) :31.|PLoS Negl Trop Dis. 2019 Aug 20;13 (8) :e0007681. |Sci Rep. 2017 Feb 17;7:42886.|bioRxiv. 2025 Feb 6:2025.02.05.636768.|Infect Drug Resist. 2022 Dec 15:15:7459-7473.|J Antimicrob Chemother. 2020 Aug 1;75 (8) :2133-2140.|J Microbiol Methods. 2021 Nov:190:106327.|Microorganisms. 2022 Dec 21;11 (1) :23.|Microorganisms. 2023 Jun 18;11 (6) :1608.|mSphere. 2018 Nov 14;3 (6) . pii: e00547-18.|mSphere. 2020 Oct 28;5 (5) :e00821-20.|Mycoses. 2021 Mar;64 (3) :282-291.