myo-Inositol trispyrophosphate (hexa-triethylamine)
Product Specifications
UNSPSC Description
myo-Inositol trispyrophosphate (ITPP) hexa-triethylamine is a salt form of inositol triphosphate (ITPP). myo-Inositol trispyrophosphate hexa-triethylamine is a membrane-permeant hemoglobin allosteric regulator. myo-Inositol trispyrophosphate hexa-triethylamine enhances the oxygen release capacity of red blood cells by reducing the affinity of hemoglobin to oxygen. myo-Inositol trispyrophosphate hexa-triethylamine can be used in the study of cardiovascular disease and cancer[1][2][3].
Target Antigen
HIF/HIF Prolyl-Hydroxylase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/myo-inositol-trispyrophosphate-hexa-triethylamine.html
Solubility
H2O : 125 mg/mL (ultrasonic)
Smiles
O=P1(O[C@]2([H])[C@@]3([H])[C@@](OP(O)(OP(O)(O3)=O)=O)([H])[C@]4([H])[C@@](OP(O)(OP(O)(O4)=O)=O)([H])[C@@]2([H])OP(O)(O1)=O)O.CCN(CC)CC.[6]
Molecular Weight
1213.13
References & Citations
[1]Fylaktakidou KC, et al. Inositol tripyrophosphate: a new membrane permeant allosteric effector of haemoglobin. Bioorg Med Chem Lett. 2005 Mar 15;15(6):1605-8. |[2]Oknińska M, et al. Treatment of hypoxia-dependent cardiovascular diseases by myo-inositol trispyrophosphate (ITPP)-enhancement of oxygen delivery by red blood cells. J Cell Mol Med. 2020 Feb;24(3):2272-2283.|[3]Raykov Z, et al. Myo-inositol trispyrophosphate-mediated hypoxia reversion controls pancreatic cancer in rodents and enhances gemcitabine efficacy. Int J Cancer. 2014 Jun 1;134(11):2572-82.
Shipping Conditions
Blue Ice
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-141510A/myo-Inositol-trispyrophosphate-hexa-triethylamine-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-141510A/myo-Inositol-trispyrophosphate-hexa-triethylamine-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
851086-77-6
Available Sizes
Curated Selection
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