PROTAC PARP1 degrader-3
PROTAC PARP1 degrader-3 (Compound C6) is a PROTAC degrader for PARP1 with a DC50 of 58.14 nM. PROTAC PARP1 degrader-3 exhibits cytotoxicity in cancer cell SW-620 and LOVO with IC50 of 1.63 μM and 2.84 μM. PROTAC PARP1 degrader-3 exhibits a synergistic effect with SN-38 in BRCA-mutated colon cancer cell with a combination index (CI) of 0.487. (Blue: Ligand for E3 ligase Cereblon (HY-23095) ; Pink: Ligand for target protein (HY-10619) ; Black: Linker (HY-16872) )
Product Specifications
UNSPSC
12352005
Target
PARP; PROTACs
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-parp1-degrader-3.html
Smiles
NC(C1=CC=CC2=CN(C3=CC=C([C@H]4CN(CCC5CCN(CCC6CCN(CC7CCN(C8=CC9=C(C(N(C%10CCC(NC%10=O)=O)C9=O)=O)C=C8)CC7)CC6)CC5)CCC4)C=C3)N=C21)=O
Molecular Formula
C52H65N9O5
Molecular Weight
896.13
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PARP1
Frequently Asked Questions
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