Caraphenol A

Caraphenol A is a resveratrol trimer and is able to transiently reduce interferon-induced transmembrane (IFITM) protein expression. Caraphenol A safely enhances lentiviral vector gene delivery to hematopoietic stem and progenitor cells[1]. Caraphenol A also inhibits human cystathionine β-synthase (hCBS) and human cystathionine γ- lyase (hCSE) with IC50s of 5.9 μM and 12.1 μM, respectively[2].

Product Specifications

CAS Number

[354553-35-8]

UNSPSC

12352005

Target

Others

Type

Natural Products

Related Pathways

Others

Applications

COVID-19-anti-virus

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/caraphenol-a.html

Purity

99.71

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

[H][C@]12[C@@H](OC3=C1C([C@@]4([C@H](OC5=C4C(C6=C(OC7=C6C2=CC(O)=C7)C8=CC=C(O)C=C8)=CC(O)=C5)C9=CC=C(O)C=C9)[H])=CC(O)=C3)C%10=CC=C(O)C=C%10

Molecular Formula

C42H28O9

Molecular Weight

676.67

References & Citations

[1]Ozog S, et al. Resveratrol trimer enhances gene delivery to hematopoietic stem cells by reducing antiviral restriction at endosomes. Blood. 2019 Oct 17;134 (16) :1298-1311.|[2]Niu W, et al. Discovery of selective cystathionine β-synthase inhibitors by high-throughput screening with a fluorescent thiol probe. Medchemcomm. 2016 Nov 15;8 (1) :198-201.