Cantharidic acid (disodium)

Cantharidic acid disodium is the hydrolysis product of the acid anhydride Cantharidin that induces apoptosis in various human cancer cells. Cantharidic acid disodium is a selective protein phosphatase 2 (PP2A) and PP1 inhibitor withIC50 values of 50 nM and 600 nM, respectively[1][2].

Product Specifications

CAS Number

[1465-77-6]

UNSPSC

12352005

Target

Apoptosis; Phosphatase

Type

Reference compound

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cantharidic-acid-disodium.html

Purity

Solubility

10 mM in DMSO

Smiles

O=C([C@@]([C@@]1(C)C(O[Na])=O)([C@@H]2O[C@H]1CC2)C)O[Na]

Molecular Formula

C10H12Na2O5

Molecular Weight

258.18

References & Citations

[1]Yi-Ching Chen, et al. Cantharidic acid induces apoptosis in human nasopharyngeal carcinoma cells through p38-mediated upregulation of caspase activation. Environ Toxicol. 2020 May;35 (5) :619-627. |[2]Adam McCluskey, et al. Serine-threonine protein phosphatase inhibitors: development of potential therapeutic strategies. J Med Chem. 2002 Mar 14;45 (6) :1151-75. |[3]M J Graziano, et al. Comparison of the acute toxicity of endothal and cantharidic acid on mouse liver in vivo. Toxicol Lett. 1987 Jul;37 (2) :143-8.