Glutaminase-IN-3
Glutaminase-IN-3 (compound 657) is a potent glutaminase inhibitor with an IC50 of 0.24 μM for Glutaminase 1 (GLS1) . Glutaminase-IN-3 is extracted from patent WO2014089048A1, compound 657[1].
Product Specifications
CAS Number
[1439399-45-7]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Glutaminase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/glutaminase-in-3.html
Concentration
10mM
Purity
99.88
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(CC1=CC=CC(OC(F)(F)F)=C1)NC2=NN=C(CCCCC3=NN=C(N)S3)C=C2
Molecular Formula
C19H19F3N6O2S
Molecular Weight
452.46
Precautions
H302, H315, H319, H335
References & Citations
[1]Mark K. Bennett, et al. Treatment of cancer with heterocyclic inhibitors of glutaminase. WO2014089048A1.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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