Guvacoline (hydrobromide)

Guvacoline hydrobromide, a pyridine alkaloid found in Areca triandra, can act as a weak full agonist of atrial and ileal mAChR[1][2].

Product Specifications

CAS Number

[17210-51-4]

UNSPSC

12352005

Target

MAChR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/guvacoline-hydrobromide.html

Purity

98.89

Solubility

10 mM in DMSO

Smiles

O=C(C1=CCCNC1)OC.Br

Molecular Formula

C7H12BrNO2

Molecular Weight

222.08

References & Citations

[1]Jiao Wu, et al. Tissue-specific and maturity-dependent distribution of pyridine alkaloids in Areca triandra. J Plant Res. 2019 Jul;132 (4) :531-540.|[2]M Wolf-Pflugmann, et al. Synthesis and muscarinic activity of a series of tertiary and quaternary N-substituted guvacine esters structurally related to arecoline and arecaidine propargyl ester. Arzneimittelforschung. 1989 May;39 (5) :539-44.