Recombinant Rat Lipocalin-2 Protein (GST Tag)

Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth.

24p; LCN; Oncogene 24p; NGALlipocalin;25 kDa alpha-2-microglobulin-related subunit of MMP; MSFI;24p3; HNL; LCN2; Lipocalin-2; NGAL; NGALlipocalin-2; p25; Siderocalin; Uterocalin; Lipocalin2;25 kDa alpha-2-microglobulin-related subunit of MMP-9; lipocalin 2 (oncogene 24p3) ; lipocalin 2; migration-stimulating factor inhibitor; neutrophil gelatinase-associated lipocalin; Oncogene 24p3;25 kDa alpha 2 microglobulin related subunit of MMP9; Alpha 2 microglobulin related protein; HGNC:6526; Lcn 2; Migration stimulating factor inhibitor; Neutrophil Gelatinase Associated Lipocalin; siderocalin LCN2; SV40 induced 24P3 protein

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.