Tyrphostin A1
Tyrphostin A1 (AG9) can inhibit CD40L-stimulated IL-12 production and antigen-induced Th1 cell production in macrophage culture.
Product Specifications
CAS Number
[2826-26-8]
Product Name Alternative
Tyrphostin 1; AG9
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
Interleukin Related
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/Tyrphostin_A1.html
Purity
98.96
Solubility
DMSO : ≥ 100 mg/mL
Smiles
N#C/C(C#N)=C\C1=CC=C(OC)C=C1
Molecular Formula
C11H8N2O
Molecular Weight
184.19
Precautions
H315, H319, H320
References & Citations
[1]Du C, et al. Inhibition of CD40 signaling pathway by tyrphostin A1 reduces secretion of IL-12 in macrophage, Th1 cell development and experimental allergic encephalomyelitis in SJL/J mice. J Neuroimmunol. 2001 Mar 1;114 (1-2) :69-79.|[2]Ogura T, et al. Activation of background membrane conductance by the tyrosine kinase inhibitor tyrphostin A23 and its inactive analog tyrphostin A1 in guinea pig ventricular myocytes. Jpn J Pharmacol. 2001 Nov;87 (3) :235-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IL-12
Available Sizes
Curated Selection
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