Tyrphostin A1
Product Specifications
UNSPSC Description
Tyrphostin A1 (AG9) can inhibit CD40L-stimulated IL-12 production and antigen-induced Th1 cell production in macrophage culture.
Target Antigen
Interleukin Related
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/Tyrphostin_A1.html
Solubility
DMSO : ≥ 100 mg/mL
Smiles
N#C/C(C#N)=C\C1=CC=C(OC)C=C1
Molecular Weight
184.19
References & Citations
[1]Du C, et al. Inhibition of CD40 signaling pathway by tyrphostin A1 reduces secretion of IL-12 in macrophage, Th1 cell development and experimental allergic encephalomyelitis in SJL/J mice. J Neuroimmunol. 2001 Mar 1;114(1-2):69-79.|[2]Ogura T, et al. Activation of background membrane conductance by the tyrosine kinase inhibitor tyrphostin A23 and its inactive analog tyrphostin A1 in guinea pig ventricular myocytes. Jpn J Pharmacol. 2001 Nov;87(3):235-9.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-16668/Tyrphostin-A1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-16668/Tyrphostin-A1-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2826-26-8
Available Sizes
Curated Selection
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