RMC-4550
RMC-4550 is a potent, selective and allosteric inhibitor of SHP2, with an IC50 of 0.583 nM.
Product Specifications
CAS Number
2172651-73-7
Product Name Alternative
PCR 5332-d4
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Phosphatase; SHP2
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/RMC-4550.html
Purity
99.56
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
ClC1=C(C(C2=NC(CO)=C(N=C2C)N3CCC4(CC3)CO[C@H]([C@H]4N)C)=CC=C1)Cl
Molecular Formula
C21H26Cl2N4O2
Molecular Weight
437.36
Precautions
H302, H315, H319, H335
References & Citations
[1]Nichols RJ, et al. RAS nucleotide cycling underlies the SHP2 phosphatase dependence of mutant BRAF-, NF1- and RAS-driven cancers. Nat Cell Biol. 2018 Sep;20 (9) :1064-1073.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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