RMC-4550
RMC-4550 is a potent, selective and allosteric inhibitor of SHP2, with an IC50 of 0.583 nM.
Product Specifications
CAS Number
2172651-73-7
Product Name Alternative
PCR 5332-d4
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Phosphatase; SHP2
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/RMC-4550.html
Purity
99.56
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
ClC1=C(C(C2=NC(CO)=C(N=C2C)N3CCC4(CC3)CO[C@H]([C@H]4N)C)=CC=C1)Cl
Molecular Formula
C21H26Cl2N4O2
Molecular Weight
437.36
Precautions
H302, H315, H319, H335
References & Citations
[1]Nichols RJ, et al. RAS nucleotide cycling underlies the SHP2 phosphatase dependence of mutant BRAF-, NF1- and RAS-driven cancers. Nat Cell Biol. 2018 Sep;20 (9) :1064-1073.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
K3279902 1.0 µg DNA
Mrgprb1 sgRNA CRISPR Lentivector (Mouse) (Target 1)
Sign In for Pricing
View Details 
040680-APC 200 µL
PTTG2, ID (PTTG2, Securin-2, Pituitary tumor-transforming gene 2 protein) (APC) discontinued
Sign In for Pricing
View Details 