Phthalide

Phthalide is a chemical scaffold. Phthalide can be used to synthesize a variety of phthalide derivatives including anti-inflammatory agent, antimicrobial, antioxidant and blood-tumor barrier modulators[1][2][3][4].

Product Specifications

CAS Number

[87-41-2]

UNSPSC

12352005

Hazard Statement

H319

Target

Bacterial; Biochemical Assay Reagents

Type

Natural Products

Related Pathways

Anti-infection; Others

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection; Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/phthalide.html

Concentration

10mM

Purity

99.95

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 2 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C1OCC2=C1C=CC=C2

Molecular Formula

C8H6O2

Molecular Weight

134.13

Precautions

H319

References & Citations

[1]Liu Zeng Chen, et al. Novel phthalide derivatives: Synthesis and anti-inflammatory activity in vitro and in vivo. Eur J Med Chem. 2020 Nov 15;206:112722.|[2]Chakapong Intaraudom, et al. Antimicrobial drimane - phthalide derivatives from Hypoxylon fendleri BCC32408. Fitoterapia. 2019 Oct;138:104353.|[3]Xin Fang, et al. Synthesis of phthalide derivatives and evaluation on their antiplatelet aggregation and antioxidant activities. J Asian Nat Prod Res. 2020 Dec;22 (12) :1176-1187.|[4]Liu X, et al. Six Phthalides as Potent Modulators of the Blood Tumor Barrier Increase the Transmembrane Transport of Compatible Compounds Via Transcellular and Paracellular Pathways. Pharmaceutical Chemistry Journal, 2024, 57 (12) : 1967-1976.