ADAMTS-5-IN-3

ADAMTS-5-IN-3 (Example 37-2) is a potent inhibitor of ADAMTS-5 and ADAMTS-4 with IC50s of 8 and 12 nM, respectively. ADAMTS-5-IN-3 can be used for the research of diseases involving degradation of cartilage or disruption of cartilage homeostasis, in particular osteoarthrosis and/or rheumatoid arthritis[1].

Product Specifications

CAS Number

[2688733-96-0]

UNSPSC

12352005

Target

ADAMTS

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/adamts-5-in-3.html

Purity

98.89

Solubility

DMSO : 200 mg/mL (ultrasonic)

Smiles

O=C(N1C[C@@H](C2=CC(Cl)=C(Cl)C=C2CC1)C)CC[C@]3(C4CC4)C(NC(N3)=O)=O

Molecular Formula

C20H23Cl2N3O3

Molecular Weight

424.32

References & Citations

[1]Dong Liu, et al. Adamts inhibitors, preparation methods and medicinal uses thereof. WO2021158626A1.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture and light)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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