ADAMTS-5-IN-3
ADAMTS-5-IN-3 (Example 37-2) is a potent inhibitor of ADAMTS-5 and ADAMTS-4 with IC50s of 8 and 12 nM, respectively. ADAMTS-5-IN-3 can be used for the research of diseases involving degradation of cartilage or disruption of cartilage homeostasis, in particular osteoarthrosis and/or rheumatoid arthritis[1].
Product Specifications
CAS Number
[2688733-96-0]
UNSPSC
12352005
Target
ADAMTS
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/adamts-5-in-3.html
Purity
98.89
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
O=C(N1C[C@@H](C2=CC(Cl)=C(Cl)C=C2CC1)C)CC[C@]3(C4CC4)C(NC(N3)=O)=O
Molecular Formula
C20H23Cl2N3O3
Molecular Weight
424.32
References & Citations
[1]Dong Liu, et al. Adamts inhibitors, preparation methods and medicinal uses thereof. WO2021158626A1.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items