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Britannilactone diacetate

Britannilactone diacetate (1,6-O, O-Diacetylbritannilactone; Compound 2) exhibits potential NO inhibition effect. Britannilactone diacetate exhibits activity against NO production induced by LPS in BV-2 microglial cells with the EC50 value of 6.3 μM. Britannilactone diacetate exhibits a favorable blood-brain barriers (BBB) penetration and absorption, distribution, metabolism, excretion, and toxicity (ADMET) property[1].

Product Specifications

CAS Number

1286694-67-4

Product Name Alternative

1,6-O, O-Diacetylbritannilactone; Di-O-acetylbritannilactone

UNSPSC

12352005

Target

NO Synthase

Type

Natural Products

Related Pathways

Immunology/Inflammation

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/britannilactone-diacetate.html

Solubility

10 mM in DMSO

Smiles

O=C1O[C@@]2([H])[C@@]([C@H](OC(C)=O)C([C@@H](C)CCCOC(C)=O)=C(C)C2)([H])C1=C

Molecular Formula

C19H26O6

Molecular Weight

350.41

References & Citations

[1]Tang JJ, et al. 1,10-Seco-Eudesmane sesquiterpenoids as a new type of anti-neuroinflammatory agents by suppressing TLR4/NF-κB/MAPK pathways. Eur J Med Chem. 2021 Nov 15;224:113713.

Shipping Conditions

Room temperature

Scientific Category

Natural Products

Clinical Information

No Development Reported

Frequently Asked Questions

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