Desoximetasone

Desoximetasone is a corticosteroid and a substrate of cytochrome P450 3A4. Desoximetasone has anti-inflammatory, anti-allergic, and immunosuppressive effects. Desoximetasone can be used in the research of various skin diseases, such as skin allergies, atopic dermatitis, and psoriasis[1][2].

Product Specifications

CAS Number

[382-67-2]

UNSPSC

12352211

Hazard Statement

H302+H312+H332, H315, H317, H319, H335, H351

Target

Cytochrome P450; Glucocorticoid Receptor; Interleukin Related

Type

Reference compound

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/desoximetasone.html

Purity

99.52

Solubility

DMSO : ≥ 100 mg/mL|H2O : 0.14 mg/mL (ultrasonic)

Smiles

F[C@@]1([C@]2(C=C3)C)[C@](CCC2=CC3=O)([H])[C@@](C[C@@H](C)[C@@H]4C(CO)=O)([H])[C@]4(C)C[C@@H]1O

Molecular Formula

C22H29FO4

Molecular Weight

376.46

Precautions

H302+H312+H332, H315, H317, H319, H335, H351

References & Citations

[1]Guo JW, et al. Magnolol may contribute to barrier function improvement on imiquimod-induced psoriasis-like dermatitis animal model via the downregulation of interleukin-23. Exp Ther Med. 2021 May;21 (5) :448.|[2]Guo JW, et al. A Promising Approach to Treat Psoriasis: Inhibiting Cytochrome P450 3A4 Metabolism to Enhance Desoximetasone Therapy. Pharmaceutics. 2023 Jul 25;15 (8) :2016.