IZ-Chol

IZ-Chol (IZ-Cholesterol) is an ionizable cationic lipid containing cholesterol. IZ-Chol-LNPs is highly potential to effectively complex with DNA, and endosome escape mechanisms mediated by proton sponge effect[1].

Product Specifications

CAS Number

[191990-35-9]

UNSPSC

12352005

Target

Liposome

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/iz-chol.html

Concentration

46.48 mM * 200 μL in Ethanol

Purity

99.37

Smiles

C[C@@]12[C@]3([H])[C@](CC=C1C[C@H](CC2)OC(NCCCN4C=CN=C4)=O)([H])[C@@]5([H])[C@](CC3)([C@@](CC5)([H])[C@H](C)CCCC(C)C)C

Molecular Formula

C34H55N3O2

Molecular Weight

537.82

References & Citations

[1]Yajing Wang, et al. Design, synthesis, and in vitro gene transfer efficacy of novel ionizable cholesterol derivatives. J Liposome Res. 2024 Apr 2:1-13.