ARP

ARP (Aldehyde reactive probe) is an aldehyde reactive probe for detecting abasic site (common DNA lesions and intermediates in mutagenesis and carcinogenesis) in DNA, which specificially tags AP site with biotin residues. ARP is highly sensitive with a femtomolar-level basic site detection capabilities (less than one site per 104 nucleotides) [1].

Product Specifications

CAS Number

[139585-03-8]

Product Name Alternative

Aldehyde reactive probe

UNSPSC

12352200

Target

Fluorescent Dye

Type

Biochemical Assay Reagents

Related Pathways

Others

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/arp.html

Solubility

10 mM in DMSO

Smiles

NOCC(NNC(CCCC[C@H]1[C@]2([H])[C@](NC(N2)=O)([H])CS1)=O)=O

Molecular Formula

C12H21N5O4S

Molecular Weight

331.39

References & Citations

[1]Kubo K, et al., A novel, sensitive, and specific assay for abasic sites, the most commonly produced DNA lesion. Biochemistry. 1992 Apr 14;31 (14) :3703-8.