MLAF50
MLAF50 is apotent REV1 UBM2-Ubiquitin interaction inhibitor. MLAF50 inhibits chromatin co-localization of REV1 with PCNA following DNA-damage induction[1].
Product Specifications
CAS Number
1417653-96-3
UNSPSC
12352005
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mlaf50.html
Smiles
O=C(O)CCC1=CC=C(I)C(OC2=CC=C(O)C=C2)=C1I
Molecular Formula
C15H12I2O4
Molecular Weight
510.06
References & Citations
[1]Vanarotti M, et al. Structures of REV1 UBM2 Domain Complex with Ubiquitin and with a Small-Molecule that Inhibits the REV1 UBM2-Ubiquitin Interaction. J Mol Biol. 2018 Aug 17;430 (17) :2857-2872.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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