Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

[D-Ala2]-GIP (human)

[D-Ala2]-GIP (human) is a GIP receptor agonist (EC50 = 630 pM). [D-Ala2]-GIP (human) improves glucose tolerance. [D-Ala2]-GIP (human) shows neuroprotective activity in MPTP -induced Parkinson's disease model. [D-Ala2]-GIP (human) also improves cognitive function and hippocampal synaptic plasticity in obese diabetic rats. [D-Ala2]-GIP (human) can be used for research of type 2 diabetes, Parkinson's disease, etc[1]

Product Specifications

CAS Number

444073-04-5

UNSPSC

12352209

Target

Insulin Receptor

Type

Peptides

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/d-ala2-gip-human.html

Purity

98.56

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(N[C@H](C)C(N[C@@H](CCC(O)=O)C(NCC(N[C@@H]([C@H](O)C)C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CO)C(N[C@@H](CC(O)=O)C(N[C@@H](CC2=CC=C(C=C2)O)C(N[C@@H](CO)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](C)C(N[C@@H](CCSC)C(N[C@@H](CC(O)=O)C(N[C@@H](CCCCN)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC3=CNC=N3)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCC(N)=O)C(N[C@@H](CC(O)=O)C(N[C@@H](CC4=CC=CC=C4)C(N[C@@H](C(C)C)C(N[C@@H](CC(N)=O)C(N[C@@H](CC5=CNC6=CC=CC=C56)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](C)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCCN)C(NCC(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CC(N)=O)C(N[C@@H](CC(O)=O)C(N[C@@H](CC7=CNC8=CC=CC=C78)C(N[C@@H](CCCCN)C(N[C@@H](CC9=CNC=N9)C(N[C@@H](CC(N)=O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H]([C@H](O)C)C(N[C@@H](CCC(N)=O)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC%10=CC=C(C=C%10)O)N

Molecular Formula

C226H338N60O66S

Molecular Weight

4983.60

References & Citations

[1]Hinke SA, et al. Dipeptidyl peptidase IV-resistant [D-Ala (2) ]glucose-dependent insulinotropic polypeptide (GIP) improves glucose tolerance in normal and obese diabetic rats. Diabetes. 2002 Mar;51 (3) :652-61.|[2]Verma MK, et al. Effect of D-Ala2GIP, a stable GIP receptor agonist on MPTP-induced neuronal impairments in mice. Eur J Pharmacol. 2017 Jun 5;804:38-45.|[3]Porter DW, et al. Prolonged GIP receptor activation improves cognitive function, hippocampal synaptic plasticity and glucose homeostasis in high-fat fed mice. Eur J Pharmacol. 2011 Jan 15;650 (2-3) :688-93.

Shipping Conditions

Blue Ice

Storage Conditions

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)

Scientific Category

Peptides

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

Pigeon Uncharacterized Protein C12orf56 (C12ORF56) ELISA Kit
MBS9399006 Inquire

Pigeon Uncharacterized Protein C12orf56 (C12ORF56) ELISA Kit

Sign In for Pricing
View Details
Interleukin 1 alpha (IL1a) (PE) discontinued
I7663-03A-PE 100 µL

Interleukin 1 alpha (IL1a) (PE) discontinued

Sign In for Pricing
View Details
Biotin-PEG4-amino-t-Bu-DADPS-C6-azide
MBS5770456 Inquire

Biotin-PEG4-amino-t-Bu-DADPS-C6-azide

Sign In for Pricing
View Details
Rabbit Polyclonal WIBG Antibody [DyLight 594]
NBP3-06364DL594 0.1 mL

Rabbit Polyclonal WIBG Antibody [DyLight 594]

Sign In for Pricing
View Details
Mouse Monoclonal HIV-1 p24 Antibody (HIV1-24/661) - Azide and BSA Free
NBP2-34636-0.1mg 0.1 mg

Mouse Monoclonal HIV-1 p24 Antibody (HIV1-24/661) - Azide and BSA Free

Sign In for Pricing
View Details
ZNF683 antibody
70R-8156 50 ug

ZNF683 antibody

Sign In for Pricing
View Details