TOP1288
TOP1288 is a narrow spectrum kinase inhibitor for P38α, Src and Syk kinase, with IC50 of 116nM, 24nM and 659nM, respectively. TOP1288 inhibits inflammatory cytokine release from inflamed biopsies and myofibroblasts[1].
Product Specifications
CAS Number
1630202-02-6
UNSPSC
12352005
Target
P38 MAPK; Src; Syk
Type
Reference compound
Related Pathways
MAPK/ERK Pathway; Protein Tyrosine Kinase/RTK
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/top1288.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=CC(C(C)(C)C)=CC(NS(=O)(C)=O)=C1OC)NC2=CC=C(C3=C2C=CC=C3)OC4=NC(NC5=CC(C#C)=CC(C(NCCOCCOCCOC)=O)=C5)=NC=C4
Molecular Formula
C43H49N7O9S
Molecular Weight
839.96
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
Frequently Asked Questions
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