HMCH-1R antagonist 1
HMCH-1R antagonist 1 (Compound 30) is an effective and selective antagonist of human melanin-concentrating hormone receptor 1 (hMCHR1) with an KB value of 3.6 nM. HMCH-1R antagonist 1 can bind to hMCHR1 and hMCHR2 with IC50 values of 65 nM and 49 nM, respectively. HMCH-1R antagonistist 1 can be used for metabolic research[1].
Product Specifications
CAS Number
353487-64-6
UNSPSC
12352209
Target
MCHR1 (GPR24)
Type
Peptides
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/hmch-1r-antagonist-1.html
Solubility
10 mM in DMSO
Smiles
O=C([C@@H](NC([C@@H](NC(CCCCNC([C@@H](NC([C@H](CSSC[C@H](NC(CCCCNC1=O)=O)C(N)=O)NC([C@@H](NC(C)=O)CCCNC(N)=N)=O)=O)CCSC)=O)=O)CCCNC(N)=N)=O)C(C)C)N[C@H]1CC2=CC=C(C=C2)O
Molecular Formula
C49H82N16O11S3
Molecular Weight
1167.47
References & Citations
[1]Bednarek MA, et al. Synthesis and biological evaluation in vitro of selective, high affinity peptide antagonists of human melanin-concentrating hormone action at human melanin-concentrating hormone receptor 1. Biochemistry. 2002 May 21;41 (20) :6383-90.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Frequently Asked Questions
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