Isobutylparaben

Isobutylparaben (Isobutyl 4-hydroxybenzoate) is the agonist for PXR, CAR and PPAR. Isobutylparaben has a broad-spectrum antimicrobial activity and widely used in personal care products and cosmetics[1].

Product Specifications

CAS Number

[4247-02-3]

Product Name Alternative

Isobutyl-P-Hydroxybenzoate

UNSPSC

12352005

Hazard Statement

H315, H318

Target

Apoptosis; Bacterial; Constitutive Androstane Receptor; PPAR; Reactive Oxygen Species (ROS)

Type

Reference compound

Related Pathways

Anti-infection; Apoptosis; Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Vitamin D Related/Nuclear Receptor

Applications

COVID-19-immunoregulation

Field of Research

Endocrinology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/isobutylparaben.html

Purity

99.10

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(OCC(C)C)C1=CC=C(O)C=C1

Molecular Formula

C11H14O3

Molecular Weight

194.23

Precautions

H315, H318

References & Citations

[1]Chieri Fujino, et al. Comparative Study of the Effect of 17 Parabens on PXR-, CAR- And PPARα-mediated Transcriptional Activation. Food Chem Toxicol. 2019 Nov;133:110792.|[2]Fei Meng, et al. Isobutylparaben Negatively Affects Porcine Oocyte Maturation Through Increasing Oxidative Stress and Cytoskeletal Abnormalities. Environ Mol Mutagen. 2020 Apr;61 (4) :433-444.|[3]Kawaguchi M, et al., Maternal isobutyl-paraben exposure alters anxiety and passive avoidance test performance in adult male rats. Neurosci Res. 2009 Oct;65 (2) :136-40.