Thalidomide-O-amido-C8-NH2 (TFA)
Thalidomide-O-amido-C8-NH2 TFA (Cereblon Ligand -Linker Conjugates 2 TFA) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.
Product Specifications
CAS Number
[1950635-16-1]
Product Name Alternative
Cereblon Ligand -Linker Conjugates 2 (TFA) ; E3 Ligase Ligand-Linker Conjugates 20 (TFA)
UNSPSC
12352005
Hazard Statement
H301, H312, H360
Target
Apoptosis; Autophagy; E3 Ligase Ligand-Linker Conjugates
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; PROTAC
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/E3_ligase_Ligand-Linker_Conjugates_17.html
Purity
99.43
Solubility
DMSO : ≥ 131 mg/mL
Smiles
NCCCCCCCCNC(COC1=C(C(N2C(CCC3=O)C(N3)=O)=O)C(C2=O)=CC=C1)=O.FC(F)(F)C(O)=O
Molecular Formula
C25H31F3N4O8
Molecular Weight
572.53
Precautions
H301, H312, H360
References & Citations
[1]James Bradner, et al. Methods to induce targeted protein degradation through bifunctional molecules. WO 2017024317 A2.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon
Available Sizes
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