AZ3451
AZ3451 is a potent protease-activated receptor-2 (PAR2) antagonist with IC50 of 23 nM.
Product Specifications
CAS Number
[2100284-59-9]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Protease Activated Receptor (PAR)
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/AZ3451.html
Concentration
10mM
Purity
99.84
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=CC=C2C(N=C(C3=C(Br)C=C(OCO4)C4=C3)N2[C@H](C5CCCCC5)C)=C1)NC6=CC=C(C#N)C=C6
Molecular Formula
C30H27BrN4O3
Molecular Weight
571.46
Precautions
H302, H315, H319, H335
References & Citations
[1]Cheng RKY, et al. Structural insight into allosteric modulation of protease-activated receptor 2. Nature. 2017 May 4;545 (7652) :112-115.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PAR2
Available Sizes
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