LM-030
LM-030 (BPR277) is a potent kallikrein-related peptidase 7 (KLK7) and epidermal elastase 2 (ELA2) inhibitor with IC50s of 6 nM and 55 nM, respectively (Example 4) [1]. LM-030 can be used for the study of Netherton syndrome[2].
Product Specifications
CAS Number
1122484-55-2
Product Name Alternative
BPR277
UNSPSC
12352209
Target
Elastase
Type
Peptides
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/lm-030.html
Solubility
10 mM in DMSO
Smiles
CC[C@@H]([C@]1([H])N2C([C@@](CC[C@H]2O)([H])NC([C@@H](NC([C@H]([C@H](OC([C@](NC([C@@H](N(C1=O)C)CC3=CC=C(C=C3)O)=O)([H])[C@@H](C)CC)=O)C)NC([C@H](CCC(N)=O)NC(C(C)C)=O)=O)=O)CC(C)C)=O)=O)C
Molecular Formula
C46H72N8O12
Molecular Weight
929.11
References & Citations
[1]Philipp Krastel, et al. Cyclic depsipeptides. WO2009024527A1|[2]Evgeniya Petrova, et al. Advances in understanding of Netherton syndrome and therapeutic implications. Expert Opinion on Orphan Drugs. 29 Dec 2020.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
Phase 1
Frequently Asked Questions
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